The largest undertreated crisis in modern medicine.
Third-party estimates and projections. Sources: SAMHSA, Grand View Research, Oregon Health Authority.
Third-party estimates and projections. Sources: SAMHSA, Grand View Research, Oregon Health Authority.
Oregon's first year of legal psilocybin services generated over $10M in revenue, with waitlists overflowing.
Third-party estimates and projections. Sources: SAMHSA, Grand View Research, Oregon Health Authority.
We started with a simple observation: the most important moments in someone's healing journey almost never happen in a therapist's office. They happen at 2am when the anxiety won't stop. They happen on a Tuesday when no one is watching. They happen in the 167 hours between appointments that nobody owned.
The infrastructure supporting behavioral health has not meaningfully changed in fifty years. Appointments are still weekly. Tools between sessions still don't exist at scale. The continuity of care that produces lasting outcomes is still missing.
And the conditions demanding that continuity are growing faster than any existing system can address. PTSD affects 13 million Americans, with veterans and first responders carrying a disproportionate burden that weekly appointments alone have never resolved. Traumatic brain injury and CTE are reaching epidemic levels in contact sports, military service, and beyond, with no daily intervention tools built specifically for them. Early-stage neurodegeneration and cognitive decline , conditions where daily training, sleep, and stress regulation are among the most evidence-supported interventions available, are projected to affect 1 in 3 people over 65 within a decade. These are not niche populations. They are the fastest-growing patient categories in modern medicine, and they share one thing in common: the gap between what the science says works and what people can actually access every single day.
Third-party estimates and projections. Sources: SAMHSA, Grand View Research, Oregon Health Authority.
The science arrived.
The infrastructure didn't.
Something significant is happening in medicine. Psilocybin has received FDA Breakthrough Therapy designation. Ketamine-assisted therapy is producing outcomes in clinical research that few prior treatments have matched. The clinical evidence is no longer emerging , it has arrived.
More than 10 states now have active natural medicine legislation, operational programs, or funded research mandates signed into law, with more advancing through legislatures and ballot processes every month. What began with Oregon and Colorado has become a nationwide infrastructure movement.
What hasn't existed until now is the infrastructure to support it responsibly, at scale, connected to the digital tools people need between sessions. That is what we're building.
10+ states with active programs, funded research, or advancing legislation, as of May 2026
The clinical infrastructure behavioral health has been missing.
We're a Colorado company working at the edge of natural medicine, behavioral AI, and cognitive science, and we're doing it differently than anyone else.
All four of our founding owners now hold Owner licenses under Colorado's Natural Medicine Division, the foundational regulatory step in the state's framework. With ownership licensure secured, we are now positioned to pursue cultivation, manufacturing, and healing center licensure under Colorado's Natural Medicine Health Act (Proposition 122), through license application and the acquisition of operating licensed facilities. Once those licenses are secured, we control the medicine, the facility, the clinical team, and the technology platform that ties it all together. No middlemen. No gaps. One continuous experience from the first session to the last.
Third State's flagship platform, ThirdState, is a behavioral intelligence platform in pre-launch testing, combining adaptive AI therapeutic techniques, cognitive training, hormone health, natural medicine companion tools, and a full clinician dashboard connected by a living psychological model that learns from you every single day.
We are among the few companies in this space building toward owning the medicine, the facility, the clinical team, and the technology platform that connects them.
ThirdState has a provisional patent application filed covering eight novel systems, spanning behavioral AI methodology, adaptive therapeutic protocols, cognitive training systems, and natural medicine companion technology. We are not just building a platform. We are building intellectual property that defines a category.
Interested in the future of behavioral health?
Reach out below. We'll be in touch within 48 hours.
This page does not constitute an offer to sell or solicitation to buy securities. Any investment opportunity will be presented only through official offering documents to qualified investors. Third State Holdings, Inc. · Delaware · Patent Pending